Comparative effectiveness trials in asthma – how will I recognize one?
نویسندگان
چکیده
منابع مشابه
Commentary: Will academia embrace comparative effectiveness research?
In recent medical history, a number of therapies that were widely adopted based on observational data or pathophysiological constructs turned out to be useless or even harmful when tested in randomized comparative effectiveness trials. These therapies not only harmed patients but also did a disservice to the practical education of medical students, residents, and fellows. These trainees effecti...
متن کاملThe Salford Lung Study: a pioneering comparative effectiveness approach to COPD and asthma in clinical trials
The Salford Lung Study (SLS) of patients with asthma and chronic obstructive pulmonary disease (COPD) is a practical, community-based, randomized, open-label pragmatic study on the efficacy and safety of the once-daily dry powder inhaler that combines the inhaled corticosteroid fluticasone furoate (FF) with the long-acting beta2 agonist vilanterol (VI). The asthma component of the SLS is not ye...
متن کاملHow Will Comparative Effectiveness Research Affect the Quality of Health Care?
What is comparative effectiveness? The Institute of Medicine (IOM) defines CE as the study of methods to “prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care,” including alternative approaches to health care delivery, for the purpose of assisting “consumers, clinicians, purchasers, and policy makers to make informed decisions that will improve health ca...
متن کاملHow can I improve outcomes in asthma?
Asthma continues to be a clinically important disease despite decreasing mortality from the condition. Asthma prevalence, as well as urgent office appointments, emergency department visits, and hospitalizations associated with asthma, are all increasing in the United States and globally.1,2 Multiple theories exist regarding the increase in prevalence, but most authorities agree that the increas...
متن کاملReassessing the Evidence Hierarchy in Asthma: Evaluating Comparative Effectiveness
Classical randomized controlled trials are the gold standard in medical evidence because of their high internal validity. However, their necessarily strict design can limit their external validity and the ability to extrapolate these data to real world patients. Therefore, alternatively designed studies may play a complementary role in evaluating the comparative effectiveness of therapies in no...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Pulmonary Medicine
سال: 2018
ISSN: 1070-5287
DOI: 10.1097/mcp.0000000000000442